Oncogene mRNA Imaging with Radionuclide-PNA-Peptides

Wickstrom, Eric

Thomas Jefferson University

关键词: Copper 64;    Oncogenes;    Genes;    Radioisotopes Hybridization, Gamma, Oligonucleotides, Positrons, Radiometals, Transcripts;    07 Isotopes And Radiation Sources;   

DOI  :  10.2172/925560
RP-ID  :  None
RP-ID  :  FG02-00ER63055
RP-ID  :  925560

美国|英语

来源: UNT Digital Library

【 摘 要 】

New cancer gene hybridization probes to carry radionuclides were made. Noninvasive technetium-99m gamma imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated, followed by noninvasive technetium-99m imaging of MYC cancer gene activity. Noninvasive imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated with a positron-emitting copper-64 probe, followed by noninvasive positron imaging of IRS1 cancer gene activity.