Immunohistochemical expression of HER-2/NEU-CERBB-2 in patients with adenocarcinoma of the stomach

Revista do Colégio Brasileiro de Cirurgiões

Fernando K Cirne-lima¹  Aline De Souza Rosa¹  Jane M U Kulczynski¹  Diego S Mattana¹  Kizzy Corezolla¹  Luis F Moreira¹ 

关键词: Stomach neoplasms;    Oncogenes;    Immunohistochemistry;    Neoplasias gástricas;    Oncogenes;    Imunoistoquímica;   

DOI  :  10.1590/S0100-69912009000200007

来源: SciELO

【 摘 要 】

OBJECTIVES: To determine the prevalence of Her-2/Neu-cerbb-2 in the gastric mucosa of patients with gastric adenocarcinoma in a brazilian patient group. METHODS: The immunohistochemical expression of Her-2/Neu was studied in 37 formalin-fixed paraffin-embedded tissue sections. RESULTS: The immunohistochemical reaction produced by the anti-HER-2/Neu antibody was positive in two cases (5.4%). CONCLUSION: The low prevalence of Her-2/Neu observed in these southern brazilian cases is probably due to the great number of poorly differentiated cancers in this serie.

【 授权许可】

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