Nanofluidic devices for rapid detection of virus particles.

Gourley, Paul Lee ; McDonald, Anthony Eugene ; Hendricks, Judy K.

Sandia National Laboratories

关键词: Flowmeters;    Nanotechnology.;    Performance Biomedical Materials.;    Biomolecules.;    59 Basic Biological Sciences;   

DOI  :  10.2172/921716
RP-ID  :  SAND2005-0485
RP-ID  :  AC04-94AL85000
RP-ID  :  921716

美国|英语

来源: UNT Digital Library

【 摘 要 】

Technologies that could quickly detect and identify virus particles would play a critical role in fighting bioterrorism and help to contain the rapid spread of disease. Of special interest is the ability to detect the presence and movement of virions without chemically modifying them by attaching molecular probes. This would be useful for rapid detection of pathogens in food or water supplies without the use of expensive chemical reagents. Such detection requires new devices to quickly screen for the presence of tiny pathogens. To develop such a device, we fabricated nanochannels to transport virus particles through ultrashort laser cavities and measured the lasing output as a sensor for virions. To understand this transduction mechanism, we also investigated light scattering from virions, both to determine the magnitude of the scattered signal and to use it to investigate the motion of virions.