Sugar Transport and Metabolism in Thermotoga

Noll, Kenneth M. ; Romano, Antonio H.

University of Connecticut, Storrs, CT 06269

关键词: Lactose;    Genes;    59 Basic Biological Sciences;    Proteins;    Transport;   

DOI  :  10.2172/899041
RP-ID  :  NONE
RP-ID  :  FG02-93ER20122
RP-ID  :  899041

美国|英语

来源: UNT Digital Library

【 摘 要 】

The work conducted under this grant demonstrated that the hyperthermophilic bacterium Thermotoga neapolitana carries out glucose and lactose transport in a sodium-dependent manner and that energization of anaerobic cells is required to observe transport. We also demonstrated that Thermotoga maritima carries out maltose and glucose transport using periplasmic sugar binding proteins. We began defining patterns of expression of genes encoding sugar transport and catabolic functions in both T. maritima and T. neapolitana. We began a collaborative effort to identify all the genes regulated at the transcriptional level in response to sugars substrates. These funds also allowed us to begin an examination of the functions of several periplasmic substrate binding proteins encoded in the genome of T. maritima.