Applications of Transport/Reaction Codes to Problems in Cell Modeling

MEANS, SHAWN A. ; RINTOUL, MARK DANIEL ; SHADID, JOHN N.

Sandia National Laboratories

关键词: Modifications;    Modulation;    Computerized Simulation;    Frogs;    59 Basic Biological Sciences;   

DOI  :  10.2172/789603
RP-ID  :  SAND2001-3780
RP-ID  :  AC04-94AL85000
RP-ID  :  789603

美国|英语

来源: UNT Digital Library

【 摘 要 】

We demonstrate two specific examples that show how our exiting capabilities in solving large systems of partial differential equations associated with transport/reaction systems can be easily applied to outstanding problems in computational biology. First, we examine a three-dimensional model for calcium wave propagation in a Xenopus Laevis frog egg and verify that a proposed model for the distribution of calcium release sites agrees with experimental results as a function of both space and time. Next, we create a model of the neuron's terminus based on experimental observations and show that the sodium-calcium exchanger is not the route of sodium's modulation of neurotransmitter release. These state-of-the-art simulations were performed on massively parallel platforms and required almost no modification of existing Sandia codes.