Final Scientific/Technical Report

Janigro, Damir

Seattle Science Foundation

关键词: 60 Applied Life Sciences;    59 Basic Biological Sciences;    Animals;    Blood-Brain Barrier;    Hypothesis;   

DOI  :  10.2172/1036460
RP-ID  :  DOE-SC0001694-2
RP-ID  :  SC0001694
RP-ID  :  1036460

美国|英语

来源: UNT Digital Library

【 摘 要 】

We started to use the first animal model of provoked status epilepticus to test the hypothesis that acute seizures induced by osmotic disruption of the blood-brain barrier result in delayed epileptogenesis. These initial experiments were aimed at perfecting the technique used. One of the problems with the approach used in the past is the fact that intarterial injections are performed across an open incision, which does not allow survival. They have therefore changed the surgical approach as detailed in this paper.