Bio-inspired nanocomposite assemblies as smart skin components.

Montano, Gabriel A. ; Xiao, Xiaoyin ; Achyuthan, Komandoor E. ; Allen, Amy ; Brozik, Susan Marie ; Edwards, Thayne L. ; Frischknecht, Amalie Lucile ; Wheeler, David Roger

Sandia National Laboratories

关键词: Membranes;    Gold;    36 Materials Science;    37 Inorganic, Organic, Physical And Analytical Chemistry;    Simulation;   

DOI  :  10.2172/1029762
RP-ID  :  SAND2011-6839
RP-ID  :  AC04-94AL85000
RP-ID  :  1029762

美国|英语

来源: UNT Digital Library

【 摘 要 】

There is national interest in the development of sophisticated materials that can automatically detect and respond to chemical and biological threats without the need for human intervention. In living systems, cell membranes perform such functions on a routine basis, detecting threats, communicating with the cell, and triggering automatic responses such as the opening and closing of ion channels. The purpose of this project was to learn how to replicate simple threat detection and response functions within artificial membrane systems. The original goals toward developing 'smart skin' assemblies included: (1) synthesizing functionalized nanoparticles to produce electrochemically responsive systems within a lipid bilayer host matrices, (2) calculating the energetics of nanoparticle-lipid interactions and pore formation, and (3) determining the mechanism of insertion of nanoparticles in lipid bilayers via imaging and electrochemistry. There are a few reports of the use of programmable materials to open and close pores in rigid hosts such as mesoporous materials using either heat or light activation. However, none of these materials can regulate themselves in response to the detection of threats. The strategies we investigated in this project involve learning how to use programmable nanomaterials to automatically eliminate open channels within a lipid bilayer host when 'threats' are detected. We generated and characterized functionalized nanoparticles that can be used to create synthetic pores through the membrane and investigated methods of eliminating the pores either through electrochemistry, change in pH, etc. We also focused on characterizing the behavior of functionalized gold NPs in different lipid membranes and lipid vesicles and coupled these results to modeling efforts designed to gain an understanding of the interaction of nanoparticles within lipid assemblies.