Simultaneous Determination of Cocaine, Cocaethylene, and Their Possible Pentafluoropropylated Metabolites and Pyrolysis Products by Gas Chromatography/Mass Spectrometry

Cardona PS, Chaturvedi AK, Soper JW, Canfield DV

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Forensic Sciences;    Toxicology;    Cocaine;    Metabolites;    Pyrolysis Products;    Analysis;    Gas Chromatography/Mass Spectrometry;   

RP-ID  :  DOT/FAA/AM-03/24

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

During the investigations of fatal transportation accidents, samples from victims are also analyzed for drugs, including cocaine (COC). COC is abused by smoking, nasal insufflantion, and intravenous injection, and it is also taken with ethanol. Therefore, it is important to determine concentrations of COC and its metabolites, ethanol analogs, and pyrolysis products for establishing the degree of toxicity, the possible ingestion of ethanol, and the possible route of administration.