This paper describes an approach that won honorable mention for the gene regulation prediction task of the 2002 KDD Cup competition [1]. Our methodology used extensive cross-validation to direct the search for an appropriate problem representation and the selection of an 'off-the-shelf' induction algorithm. A prominent trait of the dataset is the presence of three hierarchical attributes, for each of which we generated a novel predictive feature: the percentage of positives hierarchically aggregated at the node specified by the instance. Notes: Published in KDD Explorations, 4(2), 2003 2 Pages