We propose a system for automatic, on-line visual inspection and print defect detection for Variable - Data Printing (VDP). This system can be used to automatically stop the printing process and alert the operator to problems. We present the components required for constructing a vision-based inspection system and show that our approach is novel for the high-speed detection of defects on variable data. When implemented in a high-speed digital printing press, the system will allow a single skilled operator to monitor and maintain several presses, reducing the number of operators required to run a shop floor of presses as well as reduce wasted consumables when a defect goes undetected.