Biomolecular transport and separation in nanotubular networks.

Stachowiak, Jeanne C. ; Stevens, Mark Jackson (Sandia National Laboratories, Albuquerque, NM) ; Robinson, David B. ; Branda, Steven S. ; Zendejas, Frank ; Meagher, Robert J. ; Sasaki, Darryl Yoshio ; Bachand, George David (Sandia National Laboratories, Albuquerq

关键词: ADHESION;    ADSORPTION;    AFFINITY;    BENDING;    CELL MEMBRANES;    DEFORMATION;    INDUCTION;    LIPIDS;    MEMBRANES;    MORPHOLOGICAL CHANGES;    NANOTUBES;    PROTEINS;    SUBSTRATES;    TRANSPORT;   

DOI  :  10.2172/1008147
RP-ID  :  SAND2010-6473
PID  :  OSTI ID: 1008147
Others  :  TRN: US201108%%149

美国|英语

来源: SciTech Connect

【 摘 要 】

Cell membranes are dynamic substrates that achieve a diverse array of functions through multi-scale reconfigurations. We explore the morphological changes that occur upon protein interaction to model membrane systems that induce deformation of their planar structure to yield nanotube assemblies. In the two examples shown in this report we will describe the use of membrane adhesion and particle trajectory to form lipid nanotubes via mechanical stretching, and protein adsorption onto domains and the induction of membrane curvature through steric pressure. Through this work the relationship between membrane bending rigidity, protein affinity, and line tension of phase separated structures were examined and their relationship in biological membranes explored.