LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation

卷:12

Review

关键词: SELECTIN GLYCOPROTEIN LIGAND-1;    BETA-2 CYTOPLASMIC TAIL;    INTEGRIN ACTIVATION;    P-SELECTIN;    STRUCTURAL BASIS;    DISTINCT ROLES;    ADHESION;    AFFINITY;    DOMAIN;    TALIN;   

DOI  :  10.3390/cells12081136

来源: SCIE

【 摘 要 】

Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high. Most prior research has studied how LFA-1 in the high-affinity state regulates the trafficking and functions of T cells. LFA-1 is also presented in the intermediate-affinity state on T cells, however, the signaling to activate LFA-1 to the intermediate-affinity state and the role of LFA-1 in this affinity state both remain largely elusive. This review briefly summarizes the activation and roles of LFA-1 with varied ligand-binding affinities in the regulation of T-cell migration and immunological synapse formation.