Final report on Grant DE-FG03-02ER63470

John H. Miller

关键词: CHEMISTRY;    DNA;    IONIZING RADIATIONS;    REPAIR;    SPECTROSCOPY DNA damage and repair;   

DOI  :  10.2172/1002954
RP-ID  :  DOE/ER/63470-1 Final Report
PID  :  OSTI ID: 1002954
Others  :  TRN: US201105%%66

学科分类：生物科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

The goal of this project is to provide critical information to characterize the qualitative and quantitative similarities and difference in repair characteristics between clustered damage sites formed by ionizing radiation and singly damaged sites produced by endogenous processes. The premise is that base pairing and base stacking interactions are qualitatively and quantitatively different for singly and multiply damaged DNA sites. State-of-the-art computational chemistry model were used to characterize the structure, energetics, and spectroscopy of singly and multiply damaged (clustered) DNA sites.