Development of a micro flow-through cell for high field NMR spectroscopy.

Alam, Todd Michael ; McIntyre, Sarah K.

关键词: CHROMATOGRAPHY;    DESIGN;    DETECTION;    GEL PERMEATION CHROMATOGRAPHY;    NUCLEAR MAGNETIC RESONANCE;    PERFORMANCE;    PROBES;    RESOLUTION;    SPECTROSCOPY;   

DOI  :  10.2172/1018472
RP-ID  :  SAND2011-3026
PID  :  OSTI ID: 1018472
Others  :  TRN: US201114%%154

学科分类：凝聚态物理

美国|英语

来源: SciTech Connect

【 摘 要 】

A highly transportable micro flow-through detection cell for nuclear magnetic resonance (NMR) spectroscopy has been designed, fabricated and tested. This flow-through cell allows for the direct coupling between liquid chromatography (LC) and gel permeation chromatography (GPC) resulting in the possibility of hyphenated LC-NMR and GPC-NMR. The advantage of the present flow cell design is that it is independent and unconnected to the detection probe electronics, is compatible with existing commercial high resolution NMR probes, and as such can be easily implemented at any NMR facility. Two different volumes were fabricated corresponding to between {approx}3.8 and 10 {micro}L detection volume. Examples of the performance of the cell on different NMR instruments, and using different NMR detection probes were demonstrated.