Final Report - Phylogenomic tools and web resources for the Systems Biology Knowledgebase

Sjolander, Kimmen¹ 

[1] Univ. of California, Berkeley, CA (United States)

关键词: ortholog;    big data;    functional annotation;   

DOI  :  10.2172/1163480
RP-ID  :  DOE-UCBERKELEY--04916
PID  :  OSTI ID: 1163480

美国|英语

来源: SciTech Connect

【 摘 要 】

The major advance during this last reporting period (8/15/12 to present) is our release of data on the PhyloFacts website: phylogenetic trees, multiple sequence alignments and other data for protein families are now available for download from http://phylogenomics.berkeley.edu/data/. This project as a whole aimed to develop high-throughput functional annotation systems that exploit information from protein 3D structure and evolution to provide highly precise inferences of various aspects of gene function, including molecular function, biological process, pathway association, Pfam domains, cellular localization and so on. We accomplished these aims by developing and testing different systems on a database of protein family trees: the PhyloFacts Phylogenomic Encyclopedia (at http://phylogenomics.berkeley.edu/phylofacts/ ).