Compressive mechanical properties of atherosclerotic plaques-Indentation test to characterise the local anisotropic behaviour

JOURNAL OF BIOMECHANICS

卷:47

Article

Chai, Chen-Ket¹  Speelman, Lambert²  Oomens, Cees W. J.¹  Baaijens, Frank P. T.¹ 

[1] Eindhoven Univ Technol, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands

[2] Erasmus MC, Dept Biomed Engn, Thoraxctr, Rotterdam, Netherlands

关键词: Atherosclerosis;    Compressive properties;    Plaque rupture;    Indentation;    Finite element method;   

DOI  :  10.1016/j.jbiomech.2014.01.018

来源: Elsevier

【 摘 要 】

Accurate material models and associated parameters of atherosclerotic plaques are crucial for reliable biomechanical plaque prediction models. These biomechanical models have the potential to increase our understanding of plaque progression and failure, possibly improving risk assessment of plaque rupture, which is the main cause of ischaemic strokes and myocardial infarction. However, experimental biomechanical data on atherosclerotic plaque tissue is scarce and shows a high variability. In addition, most of the biomechanical models assume isotropic behaviour of plaque tissue, which is a general oversimplification. This review discusses the past and the current literature that focus on mechanical properties of plaque derived from compression experiments, using unconfined compression, micro-indentation or nano-indentation. Results will be discussed and the techniques will be mutually compared. Thereafter, an in-house developed indentation method combined with an inverse finite element method is introduced, allowing analysis of the local anisotropic mechanical properties of atherosclerotic plaques. The advantages and limitations of this method will be evaluated and compared to other methods reported in literature. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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