Using digital image correlation to determine bone surface strains during loading and after adaptation of the mouse tibia

JOURNAL OF BIOMECHANICS

卷:43

Article

Sztefek, Pavel²  Vanleene, Maximilien¹  Olsson, Robin²  Collinson, Rebecca³  Pitsillides, Andrew A.³  Shefelbine, Sandra¹ 

[1] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Aeronaut, London SW7 2AZ, England

[3] Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England

关键词: Digital image correlation;    Bone remodelling;    Bone strain;    Mouse;    Loading;   

DOI  :  10.1016/j.jbiomech.2009.10.042

来源: Elsevier

【 摘 要 】

Previous models of cortical bone adaptation, in which loading is imposed on the bone, have estimated the strains in the tissue using strain gauges, analytical beam theory, or finite element analysis. We used digital image correlation (DIC), tracing a speckle pattern on the surface of the bone during loading, to determine surface strains in a murine tibia during compressive loading through the knee joint. We examined whether these surface strains in the mouse tibia are modified following two weeks of load-induced adaptation by comparison with contralateral controls. Results indicated non-uniform strain patterns with isolated areas of high strain (0.5%), particularly on the medial side. Strain measurements were reproducible (standard deviation of the error 0.03%), similar between specimens, and in agreement with strain gauge measurements (between 0.1 and 0.2% strain). After structural adaptation, strains were more uniform across the tibial surface, particularly on the medial side where peak strains were reduced from 0.5% to 0.3%. Because DIC determines local strains over the entire surface, it will provide a better understanding of how strain stimulus influences the bone response during adaptation. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free