Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure

JOURNAL OF BIOMECHANICS

卷:46

Article

Rotemberg, Veronica¹  Byram, Brett¹  Palmeri, Mark^1,2  Wang, Michael¹  Nightingale, Kathryn¹ 

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Dept Anesthesiol, Med Ctr, Durham, NC 27708 USA

关键词: Shear wave speed;    Nonlinear mechanics;    Hepatic pressure;    Acoustic radiation force impulse (ARFI);   

DOI  :  10.1016/j.jbiomech.2013.04.027

来源: Elsevier

【 摘 要 】

Elevated hepatic venous pressure is the primary source of complications in advancing liver disease. Ultrasound imaging is ideal for potential noninvasive hepatic pressure measurements as it is widely used for liver imaging. Specifically, ultrasound based stiffness measures may be useful for clinically monitoring pressure, but the mechanism by which liver stiffness increases with hepatic pressure has not been well characterized. This study is designed to elucidate the nonlinear properties of the liver during pressurization by measuring both hepatic shear wave speed (SWS) and strain with increasing pressure. Tissue deformation during hepatic pressurization was tracked in 8 canine livers using successively acquired 3-D B-mode volumes and compared with concurrently measured SWS. When portal venous pressure was increased from clinically normal (0-5 mmHg) to pressures representing highly diseased states at 20 mmHg, the liver was observed to expand with axial strain measures up to 10%. At the same time, SWS estimates were observed to increase from 1.5-2 m/s at 0-5 mmHg (baseline) to 3.25-3.5 m/s at 20 mmHg. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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