Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis

JOURNAL OF BIOMECHANICS

卷:50

Article; Proceedings Paper

Slepian, Marvin J.^1,2,3  Sheriff, Jawaad³  Hutchinson, Marcus^1,2  Phat Tran^1,2  Bajaj, Naing^1,2  Garcia, Joe G. N.^1,2  Saavedra, S. Scott^4,5  Bluestein, Danny³ 

[1] Univ Arizona, Dept Med, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Biomed Engn, Tucson, AZ 85721 USA

[3] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA

[4] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[5] Univ Arizona, Dept Biochem, Tucson, AZ 85721 USA

关键词: Mechanotransduction;    Platelet activation;    Mechanical circulatory support;    Thrombosis;    Fluid shear stress;   

DOI  :  10.1016/j.jbiomech.2016.11.016

来源: Elsevier

【 摘 要 】

Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for free flow activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free