JOURNAL OF BIOMECHANICS | 卷:125 |
A multi-objective optimization of stent geometries | |
Article | |
Gharleghi, Ramtin1  Wright, Heidi1  Luvio, Vanessa1  Jepson, Nigel3,4  Luo, Zhen2  Senthurnathan, Anushan1  Babaei, Behzad1  Prusty, B. Gangadhara1  Ray, Tapabrata5  Beier, Susann1  | |
[1] Univ New South Wales, Sch Mech & Mfg Engn, High St,Ainsworth Bldg J17 Level 4,Room 401D, Sydney, NSW, Australia | |
[2] Univ Technol Sydney, Sch Mech & Mechatron Engn, Sydney, NSW, Australia | |
[3] Prince Wales Hosp, 320-346 Barker St Randwick, Sydney, NSW, Australia | |
[4] Univ New South Wales, Prince Wales Clin Sch Med, 18 High St, Sydney, NSW, Australia | |
[5] Univ New South Wales, Sch Engn & Informat Technol, Canberra, ACT, Australia | |
关键词: Stent design; Computational modeling; Wall shear stress; | |
DOI : 10.1016/j.jbiomech.2021.110575 | |
来源: Elsevier | |
【 摘 要 】
Stents are scaffolding cardiovascular implants used to restore blood flow in narrowed arteries. However, the presence of the stent alters local blood flow and shear stresses on the surrounding arterial wall, which can cause adverse tissue responses and increase the risk of adverse outcomes. There is a need for optimization of stent designs for hemodynamic performance. We used multi-objective optimization to identify ideal combinations of design variables by assessing potential trade-offs based on common hemodynamic indices associated with clinical risk and mechanical performance of the stents. We studied seven design variables including strut crosssection, strut dimension, strut angle, cell alignment, cell height, connector type and connector arrangement. Optimization objectives were the percentage of vessel area exposed to adversely low time averaged WSS (TAWSS) and adversely high Wall Shear Stress (WSS) assessed using computational fluid dynamics modeling, as well as radial stiffness of the stent using FEA simulation. Two multi-objective optimization algorithms were used and compared to iteratively predict ideal designs. Out of 50 designs, three best designs with respect to each of the three objectives, and two designs in regard to overall performance were identified.
【 授权许可】
Free
【 预 览 】
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