Microstructural changes associated with osteoporosis negatively affect loading-induced fluid flow around osteocytes in cortical bone

JOURNAL OF BIOMECHANICS

卷:66

Article

Gatti, Vittorio¹  Azoulay, Evan M.¹  Fritton, Susannah P.¹ 

[1] CUNY, Dept Biomed Engn, New York, NY 10031 USA

关键词: Poroelasticity;    Bone fluid flow;    Lacunar-canalicular system;    Osteoporosis;    Osteocyte;   

DOI  :  10.1016/j.jbiomech.2017.11.011

来源: Elsevier

【 摘 要 】

Loading-induced interstitial fluid flow in the microporosities of bone is critical for osteocyte mechanotransduction and for the maintenance of tissue health, enhancing convective transport in the lacunar-canalicular system. In recent studies, our group has reported alterations of bone's vascular porosity and lacunar-canalicular system microarchitecture in a rat model of postmenopausal osteoporosis. In this work, poroelastic finite element analysis was used to investigate whether these microstructural changes can affect interstitial fluid flow around osteocytes. Animal-specific finite element models were developed combining micro-CT reconstructions of bone microstructure and measures of the poroelastic material properties. These models were used to quantify and compare loading-induced fluid flow in the lacunar-canalicular system of ovariectomized and sham-operated rats. A parametric analysis was also used to quantify the influence of the lacunar-canalicular permeability and vascular porosity on the fluid velocity magnitude. Results show that mechanically-induced interstitial fluid velocity can be significantly reduced in the lacunar-canalicular system of ovariectomized rats. Interestingly, the vascular porosity is shown to have a major influence on interstitial fluid flow, while the lacunar-canalicular permeability influence is limited when larger than 10(-20) m(2). Altogether our results suggest that microstructural changes associated with the osteoporotic condition can negatively affect interstitial fluid flow around osteocytes in the lacunar-canalicular system of cortical bone. This fluid flow reduction could impair mechanosensation of the osteocytic network, possibly playing a role in the initiation and progression of age-related bone loss and postmenopausal osteoporosis. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free