The relationship between the dietary inflammatory index (DII®) and incident depressive symptoms: A longitudinal cohort study

JOURNAL OF AFFECTIVE DISORDERS

卷:235

Article

Shivappa, Nitin^1,2,3  Hebert, James R.^1,2,3  Veronese, Nicola^4,5,6  Caruso, Maria Gabriella^5,6  Notarnicola, Maria⁵  Maggi, Stefania⁴  Stubbs, Brendon^7,8,9  Firth, Joseph¹⁰  Fornaro, Michele¹¹  Solmi, Marco¹² 

[1] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA

[2] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA

[3] Connecting Hlth Innovat LLC, Columbia, SC 29201 USA

[4] CNR, Neurosci Inst, Aging Branch, Padua, Italy

[5] IRCCS S de Bellis, Natl Inst Gastroenterol, Res Hosp, Lab Nutr Biochem, Bari, Italy

[6] IRCCS S de Bellis, Natl Inst Gastroenterol, Res Hosp, Ambulatory Clin Nutr, Bari, Italy

[7] South London & Maudsley NHS Fdn Trust, London, England

[8] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[9] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford, England

[10] Univ Western Sydney, NICM Hlth Res Inst, Sydney, NSW, Australia

[11] Univ Naples Federico II, Dept Psychiat, Naples, Italy

[12] Univ Padua, Psychiat Unit, Dept Neurosci, Via Giustiniani, I-35128 Padua 2, Italy

关键词: Depression;    Health behavior;    Neuroimmunology;    Old age;   

DOI  :  10.1016/j.jad.2018.04.014

来源: Elsevier

【 摘 要 】

Background: Diet is a common source of inflammation, and inflammation is associated with depression. We examined the association between the dietary inflammatory index (DII (R)), a validated measure of inflammatory potential of the diet, and risk of depression in a cohort of older North American adults. Methods: This longitudinal study, with a follow-up of 8 years, included 3648 participants (1577 males, 2071 females; mean age: 60.6 years) with/at risk of knee osteoarthritis. DII (R) scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire. Center for Epidemiological Studies Depression-20 scale was used to define depressive symptoms. The relationship between baseline DII (R) score and incident depression was assessed through Cox's regression analysis, adjusted for potential confounders, and reported as hazard ratios (HRs). Results: In total, 837 individuals (310 men and 527 women) developed incident depressive symptoms over the course of 8 years. Participants in the most pro-inflammatory group (quartile 4) had approximately 24% higher risk of developing depressive symptoms compared to subjects with the most anti-inflammatory diet (HR: 1.24; 95% CI: 1.01-1.53; p = 0.04). Conclusion: These results suggest that a pro-inflammatory diet may be associated with higher incidence of depressive symptoms in a cohort of older Americans. Transitioning to a more anti-inflammatory diet may reduce depression risk.

【 授权许可】

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