Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study

PSYCHONEUROENDOCRINOLOGY

卷:108

Article

Bugge, Erlend^1,2  Wynn, Rolf^1,2  Mollnes, Tom Eirik^3,4,5,6,7  Reitan, Solveig Klaebo⁸  Lapid, Maria I.⁹  Gronli, Ole Kristian^1,2 

[1] Univ Hosp North Norway, Div Mental Hlth & Subst Use, N-9037 Tromso, Norway

[2] Arctic Univ Norway, UiT, Dept Clin Med, N-9038 Tromso, Norway

[3] Nordland Hosp, Res Lab, Bodo, Norway

[4] Arctic Univ Norway, UiT, KG Jebsen TREC, N-9038 Tromso, Norway

[5] Oslo Univ Hosp, Dept Immunol, N-0372 Oslo, Norway

[6] Univ Oslo, N-0372 Oslo, Norway

[7] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, N-7491 Trondheim, Norway

[8] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Inst Mental Hlth, N-7491 Trondheim, Norway

[9] Mayo Clin, Dept Psychiat & Psychol, 200 First St SW, Rochester, MN 55905 USA

关键词: Psychogeriatric;    Gerontopsychiatric;    Cytokine;    Depression;    Neuroimmunology;    Neuroinflammation;   

DOI  :  10.1016/j.psyneuen.2019.06.014

来源: Elsevier

【 摘 要 】

Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now.

【 授权许可】

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