Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

JOURNAL OF AFFECTIVE DISORDERS

卷:197

Review

Sharma, Ajaykumar N.^1,2  Borges da Costa e Silva, Bruno Fernando¹  Soares, Jair C.²  Carvalho, Andre F.^4,5  Quevedo, Joao^1,2,3,6 

[1] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX 77054 USA

[2] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, Houston, TX 77054 USA

[3] Univ Texas Grad Sch Biomed Sci Houston, Neurosci Grad Program, Houston, TX USA

[4] Univ Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, CE, Brazil

[5] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, Fortaleza, CE, Brazil

[6] Univ Southern Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Lab Neurosci, Criciuma, SC, Brazil

关键词: Major depressive disorder;    GDNF;    IGF-1;    VEGF;    Neurorophin;    Trophic factors;    Biomarker;   

DOI  :  10.1016/j.jad.2016.02.067

来源: Elsevier

【 摘 要 】

Rationale: The neurotrophin hypothesis of major depressive disorder (MDD) postulates that this illness results from aberrant neurogenesis in brain regions that regulates emotion and memory. Notwithstanding this theory has primarily implicated BDNF in the neurobiology of MDD. Recent evidence suggests that other trophic factors namely GDNF, VEGF and IGF-1 may also be involved. Purpose: The present review aimed to critically summarize evidence regarding changes in GDNF, IGF-1 and VEGF in individuals with MDD compared to healthy controls. In addition, we also evaluated the role of these mediators as potential treatment response biomarkers for MDD. Methods: A comprehensive review of original studies studies measuring peripheral, central or mRNA levels of GDNF, IGF-1 or VEGF in patients with MDD was conducted. The PubMed/MEDLINE database was searched for peer-reviewed studies published in English through June 2nd, 2015. Results: Most studies reported a reduction in peripheral GDNF and its mRNA levels in MDD patients versus controls. In contrast, IGF-1 levels in MDD patients compared to controls were discrepant across studies. Finally, most studies reported high peripheral VEGF levels and mRNA expression in MDD patients compared to healthy controls. Conclusions: GDNF, IGF-1 and VEGF levels and their mRNA expression appear to be differentially altered in MDD patients compared to healthy individuals, indicating that these molecules might play an important role in the pathophysiology of depression and antidepressant action of therapeutic interventions. Published by Elsevier B.V.

【 授权许可】

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