Medial prefrontal disengagement during self-focus in formerly depressed patients prone to rumination

JOURNAL OF AFFECTIVE DISORDERS

卷:247

Article

Nejad, Ayna B.^1,2,3,4  Rotge, Jean-Yves^5,6,13  Valabregue, Romain⁷  Guerin-Langlois, Christophe¹  Hoertel, Nicolas^1,8,9  Gorwood, Philip^8,9,10  Dubertret, Caroline^9,11,12  Limosin, Frederic^1,8,9  Fossati, Philippe^5,6,13  Lemogne, Cedric^1,8,9 

[1] Hop Univ Paris Ouest, AP HP, Serv Psychiat Adulte & Sujet Age, Paris, France

[2] Child & Adolescent Mental Hlth Ctr, Capital Reg Psychiat, Copenhagen, Denmark

[3] Univ Copenhagen, Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Copenhagen, Denmark

[4] Novo Nordisk AS, Translat Med, Clin Pharmacol & Translat Med, Bagsvaerd, Denmark

[5] Grp Hosp Pitie Salpetriere, AP HP, Serv Psychiat Adulte, Paris, France

[6] UPMC, Hop Pitie Salpetriere, Equipe Neurosci Sociales & Affect, ICM CRICM,CNRS,INSERM,UMR 7225,UMR S 1127, Paris, France

[7] Univ Paris 06, UPMC, Sorbonne Univ,UMR 7225, CENIR,ICM,INSERM,U 1127,CNRS,UMR S 1127, Paris, France

[8] Univ Paris 05, Sorbonne Paris Cite, Fac Med, Paris, France

[9] Ctr Psychiat & Neurosci, INSERM, U894, Paris, France

[10] Ctr Hosp St Anne, Clin Malad Mentales & Encephale, Paris, France

[11] Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Paris, France

[12] Hop Louis Mourier, AP HP, Serv Psychiat & Addictol, Colombes, France

[13] Univ Paris 06, Paris, France

关键词: Major depressive disorder;    Remission;    FMRI;    Medial prefrontal cortex;    Rumination;   

DOI  :  10.1016/j.jad.2019.01.004

来源: Elsevier

【 摘 要 】

Background: Medial prefrontal cortex (MPFC) activity during self-referential processing has been associated with rumination and found aberrant in depression. We investigated whether this aberrant activity reflects a trait marker that persists in remitted patients. Methods: Twenty-five patients fully remitted from major depression for at least 6 months, and 29 matched healthy controls were scanned with fMRI while presented with personality trait words in two conditions: Self condition asked whether the trait described themselves; General condition asked whether the trait was generally desirable. Contrasts-of-interest were examined in a factorial model and rumination correlates were examined in 2-sample t-tests with Ruminative Response Style score as covariate. All findings were reported at a conservative p < 0.05, with whole-brain peak-level family-wise error correction. Results: Self-referential processing increased anterior cortical midline activity to a similar extent in both groups. Dorsal anterior cingulate cortex (MNI(x, y, z) = -12,20,26) and dorsal MPFC (MNI(x, y, z) = -6,46,40) activity during self-referential processing was positively associated with rumination in healthy control subjects and negatively associated with rumination in remitted patients. Limitations: A longitudinal design tracking the relationship between rumination and MPFC activity would have aided the interpretation of our findings as to whether high ruminators are exhibiting an adaptive process to maintain remission or whether it represents a maladaptive process considering that high ruminators have an increased vulnerability for relapse. Conclusions: The association between increased anterior cortical midline activity during self-referential processing and rumination differentiated healthy controls from formerly depressed patients. Self-referential neural processing during remission from depression may depend on the cognitive tendencies to ruminate.

【 授权许可】

Free