The factor structure of depressive symptoms in patients with obesity enrolled in the RAINBOW clinical trial

JOURNAL OF AFFECTIVE DISORDERS

卷:281

Article

Majd, Marzieh¹  Smyth, Joshua M.^1,2,3  Lv, Nan⁴  Xiao, Lan⁵  Snowden, Mark B.⁶  Venditti, Elizabeth M.⁷  Williams, Leanne M.^8,9  Ajilore, Olusola A.¹⁰  Suppes, Trisha^8,9  Ma, Jun^4,11 

[1] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA

[2] Penn State Univ, Ctr Hlth Aging, University Pk, PA 16802 USA

[3] Penn State Univ, Penn State Milton S Hershey Med Ctr, University Pk, PA 16802 USA

[4] Univ Illinois, Inst Hlth Res & Policy, Chicago, IL 60608 USA

[5] Stanford Univ, Dept Epidemiol & Populat Hlth, Palo Alto, CA 94304 USA

[6] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[7] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[8] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[9] Vet Affairs Palo Alto Hlth Care Syst, Sierra Pacific Mental Illness Res Educ & Clin Ctr, Palo Alto, CA USA

[10] Univ Illinois, Dept Psychiat, Chicago, IL 60608 USA

[11] Univ Illinois, Dept Med, Chicago, IL 60608 USA

关键词: Depression;    Obesity;    PHQ-9;    SCL-20;    Exploratory factor analysis;   

DOI  :  10.1016/j.jad.2020.11.105

来源: Elsevier

【 摘 要 】

Background: Examining variability in the presenting symptoms of depression may be particularly important in characterizing depression in patients with comorbid conditions such as obesity. Identifying the underlying constructs of depression in such patients may produce phenotypic information to aid diagnosis and treatment decisions. Objective: To examine the latent factors of symptoms using the depression Symptom Checklist (SCL-20) and the Patient Health Questionnaire (PHQ-9), separately, in patients with obesity and elevated depressive symptoms. Methods: Exploratory factor analysis (EFA) was performed on baseline data from 409 patients with obesity and elevated depressive symptoms recruited in primary care. Bootstrap analysis was performed to estimate the precision and potential replicability of identified latent factors. Results: Participants (70% women, mean age of 51.0 +/- 12.1 years) had moderate depression. EFA of the SCL-20 suggested two reliable factors: dysphoric mood (71% of the variance) and anhedonia (15% of the variance). EFA of the PHQ-9 yielded one factor: dysphoric mood (87% of the variance). Bootstrapped results supported the replicability of these results. The top most endorsed symptoms were feeling low energy, overeating and disturbed sleep. Limitations: The generalizability of these findings to severe depression may be limited. Conclusions: Patients with elevated depressive symptoms and obesity present with heterogeneous symptoms. The SCL-20 seems more sensitive than the PHQ-9 for differentiating symptom profiles in this population. Some possible reasons include: 1) differences in number of scale items, and 2) differences in the aspects of depression they tap into; the SCL-20 measures the severity of symptoms, whereas the PHQ-9 measures the frequency of symptoms.

【 授权许可】

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