Physical activity modifies the association between depression and cognitive function in older adults

JOURNAL OF AFFECTIVE DISORDERS

卷:246

Article

Hu, Liang¹  Smith, Lee²  Imm, Kellie R.³  Jackson, Sarah E.⁴  Yang, Lin^5,6,7 

[1] Zhejiang Univ, Dept Sport & Exercise Sci, Hangzhou, Zhejiang, Peoples R China

[2] Anglia Ruskin Univ, Cambridge Ctr Sports & Exercise Sci, Cambridge, England

[3] Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA USA

[4] UCL, Dept Behav Sci & Hlth, London, England

[5] Med Univ Vienna, Ctr Publ Hlth, Dept Epidemiol, Vienna, Austria

[6] Alberta Hlth Serv, Dept Canc Epidemiol & Prevent Res, Calgary, AB, Canada

[7] Univ Calgary, Cunning Sch Med, Prevent Oncol & Community Hlth Sci, Calgary, AB, Canada

关键词: Older adults;    Physical activity;    Depressive symptoms;    Cognitive function;   

DOI  :  10.1016/j.jad.2019.01.008

来源: Elsevier

【 摘 要 】

Objective: To examine the effects of gender and physical activity on the interplay between depression and cognitive function in late adulthood. Method: Data on physical activity, depressive symptoms, two measures of cognitive function (the Animal Fluency Test (AFT) and the Digital Symbol Substitution Test (DSST)), and other demographic characteristics were extracted from 2604 adults aged >= 60 years participating in the National Health and Nutrition Examination Survey (2011-2014). Gender-specific multiple linear regressions examined the relationship between depressive symptoms and cognitive function in the overall sample and stratified by level of leisure-time physical activity. Results: Sample included 1327 women and 1277 men (mean age 69.0 years), Women with moderate to severe depressive symptoms had a 1.7 (95% CI: 0.5-2.9) point lower score on the AFT than those with none or minimal depressive symptoms. No such association was observed in men. In the stratified analyses, lower AFT test scores only persisted among women who were inactive. With respective to the DSST, lower test scores were observed in both men (-7.2, 95% CI: -13.1 to -1.3) and women (-6.4, 95% CI: -11.8 to -1.1) with moderate to severe depressive symptoms. In the stratified analyses, this association persisted in those who were insufficiently active, but attenuated to null among those engaged in sufficient physical activity. Conclusions: Moderate-to-vigorous physical activity modifies the depression-cognition relationship and preserves cognition function. Engaging in sufficient (150 min/week) leisure-time physical activity at moderate-to-vigorous intensity may protect those with depressive symptoms from cognitive decline in older age.

【 授权许可】

Free