Genetically predicted 17beta-estradiol, cognitive function and depressive symptoms in women: A Mendelian randomization in the Guangzhou Biobank Cohort Study

PREVENTIVE MEDICINE

卷:88

Article

Yeung, Shiu Lun Au¹  Jiang, Chaoqiang²  Cheng, Kar Keung³  Zhang, Weisen²  Lam, Tai Hing¹  Leung, Gabriel Matthew¹  Schooling, C. Mary^1,4 

[1] Univ Hong Kong, Sch Publ Hlth, Li Ka Shing Fac Med, 5-F William Mong Bldg,21 Sassoon Rd, Hong Kong, Hong Kong, Peoples R China

[2] Guangzhou 12 Hosp, Guangzhou, Guangdong, Peoples R China

[3] Univ Birmingham, Dept Publ Hlth & Epidemiol, Birmingham B15 2TT, W Midlands, England

[4] CUNY, Grad Sch Publ Hlth & Hlth Policy, New York, NY 10021 USA

关键词: Estrogen;    Cognitive function;    Depressive symptoms;    Mendelian randomization analysis;   

DOI  :  10.1016/j.ypmed.2016.03.002

来源: Elsevier

【 摘 要 】

Objective. The role of estrogen in cognitive function and depressive symptoms is controversial due to discrepancies between results from randomized controlled trials (RCT) and observational studies. Mendelian randomization analysis may provide further insights concerning the role of estrogen in these outcomes as it assesses the effect of lifelong endogenous exposure but is less vulnerable to confounding than observational studies. Method. We used separate sample instrumental variable analysis to estimate the association of log 17 beta estradiol with cognitive function (Delayed 10 word recall, and Mini Mental State Examination (MMSE)) and depressive symptoms (Geriatric Depression Scale (GDS)) in older Chinese women of the Guangzhou Biobank Cohort Study (GBCS, n = 3086). The estimate was derived based on the Wald estimator, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17 beta-estradiol with cognitive function and depressive symptoms in GBCS and the association of log 17 beta-estradiol with genetic determinants in the sample of young women in Hong Kong (n= 236). Results. Genetically predicted 17 beta-estradiol was not associated with delayed 10-word recall (0.42 words per log increase in 17 beta-estradiol (pmol/L), 95% confidence interval (CI)-0.49 to 1.34) MMSE (0.39 per log increase in 17 beta-estradiol (pmol/L), 95% CI-0.87 to 1.65) or GDS (0.24 per log increase in 17 beta-estradiol (pmol/L), 95% CI -0.57 to 1.05). Conclusion. These results were largely consistent with evidence from RCTs and did not show any beneficial effect of estrogen on cognitive function and depressive symptoms. However, larger Mendelian randomization analyses are needed to identify any minor effects. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

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