Diet quality and depression risk: A systematic review and dose-response meta-analysis of prospective studies

JOURNAL OF AFFECTIVE DISORDERS

卷:226

Review

Molendijk, Marc^1,2,3  Molero, Patricio⁴  Ortuno Sanchez-Pedreno, Felipe⁴  Van der Does, Willem^1,2,5  Angel Martinez-Gonzalez, Miguel^3,6,7 

[1] Leiden Univ, Dept Clin Psychol, Inst Psychol, Leiden, Netherlands

[2] Leiden Inst Brain & Cognit, Leiden, Netherlands

[3] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, Navarra, Spain

[4] Univ Navarra, Univ Hosp, Sch Med, Dept Psychiat & Med Psychol, Navarra, Spain

[5] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands

[6] Inst Salud Carlos III, CIBER OBN, Madrid, Spain

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

关键词: Diet;    Nutrition;    Mental health;    Depression;    Meta-analysis;   

DOI  :  10.1016/j.jad.2017.09.022

来源: Elsevier

【 摘 要 】

Background: It has been claimed that the quality of a diet is associated with the incidence of depressive disorders. We sought to investigate the evidence for this claim. Methods: Systematic searches were performed up to March 6th, 2017 in order to identify prospective cohort studies that reported on exposure to dietary patterns or food groups and the incidence of depression/depressive symptoms. Data from 24 independent cohorts (totalling 1,959,217 person-years) were pooled in random-effects meta-analyses. Results: Adherence to a high-quality diet, regardless of type (i.e., healthy/prudent or Mediterranean), was associated with a lower risk of depressive symptoms over time (odds ratios ranged 0.64-0.78 in a linear dose-response fashion [P< 0.01]). A relatively low dietary inflammatory index was also associated with a somewhat lower incidence of depressive symptom (odds ratio = 0.81), although not in a dose-response fashion. Similar associations were found for the consumption of fish and vegetables (odds ratios 0.86 and 0.82 respectively) but not for other high quality food groups (e.g., fruit). Studies that controlled for depression severity at baseline or that used a formal diagnosis as outcome did not yield statistically significant findings. Adherence to low quality diets and food groups was not associated with higher depression incidence. Limitations: Our ability to detect confounders was only limited. Conclusion: There is evidence that a higher quality of a diet is associated with a lower risk for the onset of depressive symptoms, but not all available results are consistent with the hypothesis that diet influences depression risk. Prospective studies that control for relevant confounders such as obesity incidence and randomized controlled prevention trials are needed to increase the validity of findings in this field.

【 授权许可】

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