Amplitude of low-frequency fluctuation (ALFF) alterations in adults with subthreshold depression after physical exercise: A resting-state fMRI study

JOURNAL OF AFFECTIVE DISORDERS

卷:295

Article

Huang, Lina^1,2  Huang, Guofeng³  Ding, Qingguo²  Liang, Pei^2,4  Hu, Chunhong⁵  Zhang, Hongqiang²  Zhan, Linlin⁶  Wang, Qianqian⁷  Cao, Yikang⁸  Zhang, Jun⁹  Shen, Wenbin²  Jia, Xize¹⁰  Xing, Wei¹ 

[1] Soochow Univ, Affiliated Hosp 3, Dept Radiol, 185 Juqian Rd, Changzhou, Jiangsu, Peoples R China

[2] Xuzhou Med Univ, Changshu Hosp, Dept Radiol, Xuzhou, Jiangsu, Peoples R China

[3] Jiamusi Univ, Sch Informat & Elect Technol, Jiamusi, Heilongjian, Peoples R China

[4] Hubei Univ, Fac Educ, Dept Psychol, Wuhan, Hubei, Peoples R China

[5] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou, Jiangsu, Peoples R China

[6] Heilongjiang Univ, Sch Western Language, Harbin, Heilongjiang, Peoples R China

[7] Zhejiang Normal Univ, Sch Teacher Educ, Jinhua, Zhejiang, Peoples R China

[8] Jiamusi Univ, Sch Comp Sci & Technol, Jiamusi, Heilongjiang, Peoples R China

[9] Changshu Third Peoples Hosp, Dept Psychiat, Changshu, Jiangsu, Peoples R China

[10] Hangzhou Normal Univ, Inst Psychol Sci, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China

关键词: Subthreshold depression;    Prevention;    Exercise;    Neuroimaging;    Resting-state;   

DOI  :  10.1016/j.jad.2021.08.094

来源: Elsevier

【 摘 要 】

Background: Physical exercise has been proved to reduce the risk of major depression in Subthreshold depression (StD) individuals effectively, yet little is known about the spontaneous brain activity changes associated with physical exercise. Methods: A total of 70 adult subjects, including 38 StD and 32 healthy control (HC) subjects, underwent a resting-state functional magnetic resonance imaging (rs-fMRI) before and after eight-week aerobic exercise respectively. Then, the amplitude of low-frequency fluctuation (ALFF) alterations between the two groups were quantitatively analyzed. Results: Before exercise intervention, the rs-fMRI data showed increased ALFF of the right putamen in the StD group compared with HC group. After exercise intervention, there was no significant ALFF change observed between the StD and HC groups. The longitudinal ALFF differences from pre- to post-exercise intervention showed significantly decreased ALFF in the right middle and inferior occipital gyrus, right middle and inferior temporal gyrus, right fusiform gyrus (FG), while increased ALFF in the right middle cingulate, right superior parietal louble, right inferior parietal lobule (IPL) (inferior parietal gyrus and supramarginal gyrus), and bilateral precuneus in the StD group. As for HC group, the results showed that decreased ALFF in the right FG and right parahippocampus, while increased ALFF in the right precuneus, right middle cingulate, right supplementary motor area, right superior parietal lobule and right paracentral lobule in the HC group. No significant correlation between changes of ALFF and clinical scale scores in the StD group. Limitations: The definitions of StD are varied in terms of different studies, the final sample size was relatively small, and the age range of the subjects in this study was narrow. Meanwhile, the exercise intervention trial was short-term. Conclusions: These results further support the standpoint that physical exercise has the potential to reshape the abnormal patterns of spontaneous brain activity in adults with StD.

【 授权许可】

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