Neuroimaging insights into the link between depression and Insomnia: A systematic review

JOURNAL OF AFFECTIVE DISORDERS

卷:258

Review

Bagherzadeh-Azbari, Shadi^1,2  Khazaie, Habibolah³  Zarei, Mojtaba¹  Spiegelhalder, Kai⁴  Walter, Martin^5,6  Leerssen, Jeanne^7,8,9  Van Someren, Eus J. W.^7,8,9  Sepehry, Amir A.¹⁰  Tahmasian, Masoud¹ 

[1] Shahid Beheshti Univ, Inst Med Sci & Technol, Tehran, Iran

[2] Humboldt Univ, Dept Psychol, Berlin, Germany

[3] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah, Iran

[4] Univ Freiburg, Fac Med, Med Ctr, Dept Psychiat & Psychotherapy, Freiburg, Germany

[5] Univ Tubingen, Dept Psychiat, Tubingen, Germany

[6] Otto von Guericke Univ, Leibntz Inst Neurobiol, Clin Affect Neuroimaging Lab, Magdeburg, Germany

[7] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Dept Sleep & Cognit, NL-1105 BA Amsterdam, Netherlands

[8] Vrije Univ Amsterdam, Amsterdam UMC, CNCR, Dept Psychiat, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands

[9] Vrije Univ Amsterdam, Amsterdam UMC, CNCR, Dept Integrat Neurophysiol, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands

[10] Adler Univ, Clin & Counselling Psychol Program, Vancouver, BC, Canada

关键词: Major depressive disorder;    Insomnia;    fMRI;    PET;    SPECT;    Spectroscopy;   

DOI  :  10.1016/j.jad.2019.07.089

来源: Elsevier

【 摘 要 】

Background: Insomnia is a common symptom of Major Depressive Disorder (MDD) and genome-wide association studies pointed to their strong genetic association. Although the prevalence of insomnia symptoms in MDD is noticeable and evidence supports their strong bidirectional association, the number of available neuroimaging findings on patients of MDD with insomnia symptoms is limited. However, such neuroimaging studies could verily improve our understanding of their shared pathophysiology and advance corresponding theories. Methods: Based on the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guideline, we have conducted a literature search using PubMed, EMBASE, and Scopus databases and systematically explored 640 studies using various neuroimaging modalities in MDD patients with different degrees of insomnia symptoms. Results: Despite inconsistencies, current findings from eight studies suggested structural and functional disturbances in several brain regions including the amygdala, prefrontal cortex and anterior cingulate cortex and insula. The aberrant functional connectivity within and between the main hubs of the salience and default mode networks could potentially yield new insights into the link between MDD and insomnia, which needs further assessment. Limitations: The number of studies reviewed herein is limited. The applied methods for assessing structural and functional neural mechanisms of insomnia and depression were variable. Conclusion: Neuroimaging methods demonstrated the overlapping underlying neural mechanisms between MDD and insomnia. Future studies may facilitate better understanding of their pathophysiology to allow development of specific treatment.

【 授权许可】

Free