Visual memory dysfunction as a neurocognitive endophenotype in bipolar disorder patients and their unaffected relatives. Evidence from a 5-year follow-up Valencia study

JOURNAL OF AFFECTIVE DISORDERS

卷:257

Article

Correa-Ghisays, Patricia^1,2,3,4  Vicent Sanchez-Orti, Joan^2,4  Ayesa-Arriola, Rosa^1,8,9  Setien-Suero, Esther^1,8,9  Balanza-Martinez, Vicent^1,4,5  Selva-Vera, Gabriel^1,9  Carlos Ruiz-Ruiz, Juan⁶  Vila-Frances, Joan⁷  Martinez-Aran, Anabel^1,10  Vivas-Lalinde, Juliana⁶  Conforte-Molina, Candela²  San-Martin, Constanza^4,11  Martinez-Perez, Carlos²  Fuentes-Dura, Inmaculada²  Crespo-Facorro, Benedicto^1,12  Tabares-Seisdedos, Rafael^1,3,4,5 

[1] Ctr Invest Biomed Red Salud Mental, CIBERSAM, Madrid, Spain

[2] Univ Valencia, Fac Psychol, Valencia, Spain

[3] INCLIVA Hlth Res Inst, Valencia, Spain

[4] Univ Valencia, Dept Med, TMAP Unidad Evaluat Auton Personal Dependencia &, Valencia, Spain

[5] Univ Valencia, Teaching Unit Psychiat & Psychol Med, Dept Med, Blasco Ibanez 17, Valencia 46010, Spain

[6] Dept Psychiat, Mental Hlth Serv, Valencia, Spain

[7] Univ Valencia, Intelligent Data Anal Lab, Valencia, Spain

[8] Univ Hosp Marques de Valdecilla, IDIVAL, Dept Psychiat, Santander, Spain

[9] Univ Cantabria, Marques de Valdecilla Univ Hosp, Sch Med, Dept Psychiat,IDIVAL, Santander, Spain

[10] Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst, Bipolar Disorders Unit,IDIBAPS, Catalonia, Spain

[11] Univ Valencia, Dept Physioterapiy, Valencia, Spain

[12] Univ Seville, Hosp Univ Virgen del Rocio, Seville, Spain

关键词: Visual memory;    Bipolar disorder;    Endophenotype;    Neurocognition;    Longitudinal study;    Family study;   

DOI  :  10.1016/j.jad.2019.06.059

来源: Elsevier

【 摘 要 】

Background: Scarce research has focused on Visual Memory (VM) deficits as a possible neurocognitive endophenotype of bipolar disorder (BD). The main aim of this longitudinal, family study with healthy controls was to explore whether VM dysfunction represents a neurocognitive endophenotype of BD. Methods: Assessment of VM by Rey-Osterrieth Complex Figure Test (ROCF) was carried out on a sample of 317 subjects, including 140 patients with BD, 60 unaffected first-degree relatives (BD-Rel), and 117 geneticallyunrelated healthy controls (HC), on three occasions over a 5-year period (T1, T2, and T3). BD-Rel group scores were analyzed only at T1 and T2. Results: Performance of BD patients was significantly worse than the HC group (p < 0.01). Performance of BDRel was also significantly different from HC scores at T1 (p < 0.01) and T2 (p = 0.05), and showed an intermediate profile between the BD and HC groups. Only among BD patients, there were significant differences according to sex, with females performing worse than males (p = 0.03). Regarding other variables, education represented significant differences only in average scores of BD-Rel group (p = 0.01). Limitations: Important attrition in BD-Rel group over time was detected, which precluded analysis at T3. Conclusions: BD patients show significant deficits in VM that remain stable over time, even after controlling sociodemographic and clinical variables. Unaffected relatives also show stable deficits in VM. Accordingly, the deficit in VM could be considered a potential endophenotype of BD, which in turn may be useful as a predictor of the evolution of the disease. Further studies are needed to confirm these findings.

【 授权许可】

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