The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:73

Review

Miskowiak, Kamilla W.¹  Kjaerstad, Hanne L.¹  Meluken, Iselin¹  Petersen, Jeff Zarp¹  Maciel, Beatriz R.^2,3  Kohler, Cristiano A.^2,3  Vinberg, Maj¹  Kessing, Lars V.¹  Carvalho, Andre F.^2,3 

[1] Rigshosp, Copenhagen Univ Hosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr, Copenhagen, Denmark

[2] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, Ceara, Brazil

关键词: Bipolar disorder;    Endophenotype;    Cognition;    Neurocognition;    Neuroimaging;    Psychiatry;    Mood disorder;    Pathophysiology;   

DOI  :  10.1016/j.neubiorev.2016.12.011

来源: Elsevier

【 摘 要 】

The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: 'cold' and 'hot' cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free