Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele

JOURNAL OF AFFECTIVE DISORDERS

卷:198

Article

Cao, Bo¹  Bauer, Isabelle E.¹  Sharma, Ajaykumar N.¹  Mwangi, Benson¹  Frazier, Thomas^2,3  Lavagnino, Luca¹  Zunta-Soares, Giovana B.¹  Walss-Bass, Consuelo¹  Glahn, David C.^4,5  Kapczinski, Flavio⁶  Nielsen, David A.⁷  Soares, Jair C.¹ 

[1] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

[2] Cleveland Clin, Ctr Pediat Behav Hlth, Cleveland, OH 44106 USA

[3] Cleveland Clin, Ctr Autism, Cleveland, OH 44106 USA

[4] Yale Univ, Sch Med, Inst Living, Olin Neuropsychiat Res Ctr, New Haven, CT 06520 USA

[5] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA

[6] Univ Fed Rio Grande do Sul, Dept Psychiat, Rua Ramiro Barcelos 2350, BR-90035903 Rio Grande do Sul, RS, Brazil

[7] Baylor Coll Med, Dept Psychiat & Behav Sci, DeBakey VA Med Ctr, Houston, TX 77030 USA

关键词: Bipolar disorder type I;    BDNF val66met;    Polymorphism;    Hippocampus;    Volume;    Memory;    MRI;    Bipolar;    Major depressive disorder;   

DOI  :  10.1016/j.jad.2016.03.044

来源: Elsevier

【 摘 要 】

Background: Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. This study aimed to investigate the effect of BDNF polymorphism on hippo campus volumes and memory performance in well-characterized adult populations diagnosed with type I BD (BD-I) and major depressive disorder (MDD) compared with healthy controls (HC). Methods: 48 BD-I patients, 33 MDD patients and 60 HC were genotyped for BDNF rs6265 using DNA isolated from white blood cells. Individuals with val/met and met/met genotypes were grouped as met carriers and compared to those with the val/val. Brain segmentations were obtained from structural magnetic resonance imaging (MRI) using the Freesurfer. Memory performance was assessed with the California Verbal Learning Task (CVLT). Results: We found a significant diagnosis effect and marginal interaction between diagnosis and BDNF genotype group for both hippocampus volumes and memory performance. BDNF met allele carrier BD patients had smaller hippocampus volumes and reduced performance on multiple CVLT scores compared to MDD patients and HC. Conclusions: We provide strong evidence for the BDNF val66met polymorphism as a putative biological signature for the neuroanatomical and cognitive abnormalities commonly observed in BD patients. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

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