Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy A Primary Prevention Cohort Study

JACC-CARDIOVASCULAR IMAGING

卷:11

Article

Lie, Oyvind H.^1,2,3  Rootwelt-Norberg, Christine^1,2  Dejgaard, Lars A.^1,2,3  Leren, Ida Skrinde^1,2,3  Stokke, Mathis K.^1,2,3  Edvardsen, Thor^1,2,3,4  Haugaa, Kristina H.^1,2,3,4 

[1] Oslo Univ Hosp, Rikshosp, Dept Cardiol, Sognsvannsveien 20, N-0424 Oslo, Norway

[2] Oslo Univ Hosp, Rikshosp, Ctr Cardiol Innovat, Oslo, Norway

[3] Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway

[4] Univ Oslo, Inst Surg Res, Oslo, Norway

关键词: arrhythmogenic cardiomyopathy;    ARVC;    ventricular arrhythmia;    prediction;    strain echocardiography;   

DOI  :  10.1016/j.jcmg.2018.05.017

来源: Elsevier

【 摘 要 】

OBJECTIVES This study aimed to identify clinical, electrocardiographic (ECG) and cardiac imaging predictors of first-time life-threatening ventricular arrhythmia in patients with arrhythmogenic cardiomyopathy (AC). BACKGROUND The role of clinical, electrocardiographic, and cardiac imaging parameters in risk stratification of patients without ventricular arrhythmia is unclear. METHODS We followed consecutive AC probands and mutation-positive family members with no documented ventricular arrhythmia from time of diagnosis to first event. We assessed clinical, electrocardiographic, and cardiac imaging parameters according to Task Force Criteria of 2010 in addition to left ventricular (LV) and strain parameters. High-intensity exercise was defined as >6 metabolic equivalents. RESULTS We included 117 patients (29% probands, 50% female, age 40 +/- 17 years). During 4.2 (interquartile range [IQR]: 2.4 to 7.4) years of follow-up, 18 (15%) patients experienced life-threatening ventricular arrhythmias. The 1-, 2-, and 5-year incidence was 6%, 9%, and 22%, respectively. History of high-intensity exercise, T-wave inversions >= V-3, and greater LV mechanical dispersion were the strongest risk markers (adjusted hazard ratio [HR]: 4.7 [95% confidence interval (CI): 1.2 to 17.5]; p = 0.02, 4.7 [95% CI: 1.6 to 13.9]; p = 0.005), and 1.4 [95% CI: 1.2 to 1.6] by 10-ms increments; p < 0.001, respectively). Median arrhythmia-free survival in patients with alt risk factors was 1.2 (95% CI: 0.4 to 1.9) years, compared with an estimated 12.0 (95% CI: 11.5 to 12.5) years in patients without any risk factors. CONCLUSIONS History of high-intensity exercise, electrocardiographic T-wave inversions >= V-3, and greater LV mechanical dispersion were strong predictors of life-threatening ventricular arrhythmia. Patients without any of these risk factors had minimal risk, whereas >= 2 risk factors increased the risk dramatically. This may help to make decisions on primary preventive implantable cardioverter defibrillator (ICD) therapy. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

【 授权许可】

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