Nanotechnology approaches for inhalation treatment of lung diseases

JOURNAL OF CONTROLLED RELEASE

卷:219

Article

Kuzmov, Andriy¹  Minko, Tamara^1,2 

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA

[2] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA

关键词: Nanoparticles;    Gene delivery;    Lung cancer;    Fibrosis;    Pulmonary delivery;    Hypoxia;   

DOI  :  10.1016/j.jconrel.2015.07.024

来源: Elsevier

【 摘 要 】

Local administration of therapeutics by inhalation for treatment of lung diseases has the ability to deliver drugs, nucleic acids and peptides specifically to the site of their action and therefore enhance the efficacy of the treatment, limit the penetration of nebulized therapeutic agent(s) into the bloodstream and consequently decrease adverse systemic side effects of the treatment. Nanotechnology allows for a further enhancement of the treatment efficiency. The present review analyzes modern therapeutic approaches of inhaled nanoscale-based pharmaceutics for the detection and treatment of various lung diseases. (C) 2015 The Authors. Published by Elsevier B.V.

【 授权许可】

Free