Spatiotemporal drug delivery using laser-generated-focused ultrasound system

JOURNAL OF CONTROLLED RELEASE

卷:220

Article; Proceedings Paper

Di, Jin^1,2,4,5  Kim, Jinwook³  Hu, Quanyin^1,2,4,5  Jiang, Xiaoning³  Gu, Zhen^1,2,4,5,6 

[1] N Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27695 USA

[2] N Carolina State Univ, Raleigh, NC 27695 USA

[3] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA

[4] N Carolina State Univ, Ctr Nanotechnol Drug Delivery, Raleigh, NC 27599 USA

[5] N Carolina State Univ, Div Mol Pharmaceut, UNC Eshelman Sch Pharm, Raleigh, NC 27599 USA

[6] N Carolina State Univ, Dept Med, Raleigh, NC 27599 USA

关键词: Drug delivery;    Photoacoustic;    Nanoparticles;    Microgels;    Stimuli responsive;   

DOI  :  10.1016/j.jconrel.2015.08.033

来源: Elsevier

【 摘 要 】

Laser-generated-focused ultrasound (LGFU) holds promise for the high-precision ultrasound therapy owing to its tight focal spot, broad frequency band, and stable excitation with minimal ultrasound-induced heating. We here report the development of the LGFU as a stimulus for promoted drug release from microgels integrated with drug-loaded polymeric nanoparticles. The pulsed waves of ultrasound, generated by a carbon black/polydimethylsiloxane (PDMS)-photoacoustic lens, were introduced to trigger the drug release from alginate microgels encapsulated with drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles. We demonstrated the antibacterial capability of this drug delivery system against Escherichia coli by the disk diffusion method, and antitumor efficacy toward the HeLa cell-derived tumor spheroids in vitro. This novel LGFU-responsive drug delivery system provides a simple and remote approach to precisely control the release of therapeutics in a spatiotemporal manner and potentially suppress detrimental effects to the surrounding tissue, such as thermal ablation. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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