Novel delivery approaches for cancer therapeutics

JOURNAL OF CONTROLLED RELEASE

卷:219

Article

Mitra, Ashim K.¹  Agrahari, Vibhuti¹  Mandal, Abhirup¹  Cholkar, Kishore^1,2  Natarajan, Chandramouli¹  Shah, Sujay¹  Joseph, Mary¹  Trinh, Hoang M.¹  Vaishya, Ravi^1,3  Yang, Xiaoyan¹  Hao, Yi¹  Khurana, Varun³  Pal, Dhananjay¹ 

[1] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64108 USA

[2] Ricon Pharmaceut LLC, Denville, NJ 07834 USA

[3] INSYS Therapeut Inc, Chandler, AZ 85224 USA

关键词: Chemotherapeutics;    Tumor;    Cancer;    Targeted Drug Delivery;    Stem cells;    Cell Penetrating Peptides;    Efflux Pumps;    Gene therapy;    Immunotherapy;   

DOI  :  10.1016/j.jconrel.2015.09.067

来源: Elsevier

【 摘 要 】

Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo-and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It iswidely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to lowquality of life. This reviewencompasses novel strategies formore effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stemcell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection ofmalignant cells leading to their eradication with minimal side effects. Lowering multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free