Surface engineering tumor cells with adjuvant-loaded particles for use as cancer vaccines

JOURNAL OF CONTROLLED RELEASE

卷:248

Article

Ahmed, Kawther K.¹  Geary, Sean M.¹  Salem, Aliasger K.¹ 

[1] Univ Iowa Coll Pharm, Div Pharmaceut & Translat Therapeut, Iowa City, IA USA

关键词: Cell surface engineering;    Cancer vaccines;    Streptavidin-biotin cross-linking;    PLGA particles;   

DOI  :  10.1016/j.jconrel.2016.12.036

来源: Elsevier

【 摘 要 】

Cell surface engineering is an expanding field and whilst extensive research has been performed decorating cell surfaces with biomolecules, the engineering of cell surfaces with particles has been a largely unexploited area. This study reports on the assembly of cell-particle hybrids where irradiated tumor cells were surface engineered with adjuvant-loaded, biodegradable, biocompatible, polymeric particles, with the aimof generating a construct capable of functioning as a therapeutic cancer vaccine. Successfully assembled cell-particle hybrids presented here comprised either melanoma cells or prostate cancer cells stably adorned with Toll-like receptor-9 ligandloaded particles using streptavidin-biotin cross-linking. Both cell-particle assemblies were tested in vivo for their potential as therapeutic cancer vaccines yielding promising therapeutic results for the prostate cancer model. The ramifications of results obtained for both tumor models are openly discussed. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free