Iron oxide-carbon core-shell nanoparticles for dual-modal imaging-guided photothermal therapy

JOURNAL OF CONTROLLED RELEASE

卷:289

Article

Wang, Hui^1,2  Mu, Qingxin¹  Revia, Richard¹  Wang, Kui¹  Tian, Bowei⁵  Lin, Guanyou¹  Lee, Woncheol^3,4  Hong, Yang-Ki^3,4  Zhang, Miqin¹ 

[1] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA

[2] Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, AH, Peoples R China

[3] Univ Alabama, Dept Elect & Comp Engn, Tuscaloosa, AL 35487 USA

[4] Univ Alabama, MINT Ctr, Tuscaloosa, AL 35487 USA

[5] Univ Washington, Dept Appl Math, Seattle, WA 98195 USA

关键词: Hybrid nanoparticles;    Carbon shell;    Magnetic core;    Multi-modal imaging;    Photothermal therapy;   

DOI  :  10.1016/j.jconrel.2018.09.022

来源: Elsevier

【 摘 要 】

Nanostructured materials that have low tissue toxicity, multi-modal imaging capability and high photothermal conversion efficiency have great potential to enable image-guided near infrared (NIR) photothermal therapy (PTT). Here, we report a bifunctional nanoparticle (BFNP,similar to 16 nm) comprised of a magnetic Fe3O4 core (similar to 9.1 nm) covered by a fluorescent carbon shell (similar to 3.4 nm) and prepared via a one-pot solvothermal synthesis method using ferrocene as the sole source. The BFNP exhibits excitation wavelength-tunable, upconverted and near-infrared (NIR) fluorescence property due to the presence of the carbon shell, and superparamagnetic behavior resulted from the Fe3O4 core. BFNPs demonstrate dual-modal imaging capacity both in vitro and in vivo with fluorescent imaging excited under a varying wavelength from 405 nm to 820 nm and with T-2-weighted magnetic resonance imaging (r(2) = 264.76 mM(-1) s(-1)). More significantly, BFNPs absorb and convert NIR light to heat enabling photothermal therapy as demonstrated mice bearing C6 glioblastoma. These BFNPs show promise as an advanced nanoplatform to provide imaging guided photothermal therapy.

【 授权许可】

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