Immune mechanisms of oral immunotherapy

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:141

Article

Kulis, Michael D.¹  Patil, Sarita U.²  Wambre, Erik³  Vickery, Brian P.¹ 

[1] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA

[2] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA

[3] Benaroya Res Inst, Dept Immunol, Seattle, WA USA

关键词: Oral immunotherapy;    immune mechanisms;    desensitization;    sustained unresponsiveness;    basophils;    T cells;    B cells;    mast cells;    antibodies;   

DOI  :  10.1016/j.jaci.2017.12.979

来源: Elsevier

【 摘 要 】

Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.

【 授权许可】

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