Human versus mouse eosinophils: That which we call an eosinophil, by any other name would stain as red

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:130

Article

Lee, James J.¹  Jacobsen, Elizabeth A.¹  Ochkur, Sergei I.¹  McGarry, Michael P.¹  Condjella, Rachel M.²  Doyle, Alfred D.¹  Luo, Huijun¹  Zellner, Katie R.²  Protheroe, Cheryl A.²  Willetts, Lian^1,4  LeSuer, William E.²  Colbert, Dana C.²  Helmers, Richard A.³  Lacy, Paige⁴  Moqbel, Redwan⁵  Lee, Nancy A.² 

[1] Mayo Clin Arizona, Dept Biochem & Mol Biol, Div Pulm Med, Scottsdale, AZ 85259 USA

[2] Mayo Clin Arizona, Dept Biochem & Mol Biol, Div Hematol Oncol, Scottsdale, AZ 85259 USA

[3] Mayo Clin Arizona, Dept Crit Care Med, Div Pulm Med, Scottsdale, AZ 85259 USA

[4] Univ Alberta, Dept Med, Pulm Res Grp, Edmonton, AB, Canada

[5] Univ Manitoba, Dept Immunol, Winnipeg, MB R3T 2N2, Canada

关键词: Eosinophils;    mouse;    human;    rodent;    primate;    hematology;   

DOI  :  10.1016/j.jaci.2012.07.025

来源: Elsevier

【 摘 要 】

The respective life histories of human subjects and mice are well defined and describe a unique story of evolutionary conservation extending from sequence identity within the genome to the underpinnings of biochemical, cellular, and physiologic pathways. As a consequence, the hematopoietic lineages of both species are invariantly maintained, each with identifiable eosinophils. This canonical presence nonetheless does not preclude disparities between human and mouse eosinophils, their effector functions, or both. Indeed, many books and reviews dogmatically highlight differences, providing a rationale to discount the use of mouse models of human eosinophilic diseases. We suggest that this perspective is parochial and ignores the wealth of available studies and the consensus of the literature that overwhelming similarities (and not differences) exist between human and mouse eosinophils. The goal of this review is to summarize this literature and in some cases provide experimental details comparing and contrasting eosinophils and eosinophil effector functions in human subjects versus mice. In particular, our review will provide a summation and an easy-to-use reference guide to important studies demonstrating that although differences exist, more often than not, their consequences are unknown and do not necessarily reflect inherent disparities in eosinophil function but instead species-specific variations. The conclusion from this overview is that despite nominal differences, the vast similarities between human and mouse eosinophils provide important insights as to their roles in health and disease and, in turn, demonstrate the unique utility of mouse-based studies with an expectation of valid extrapolation to the understanding and treatment of patients. (J Allergy Clin Immunol 2012;130:572-84.)

【 授权许可】

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