Report from the National Institute of Allergy and Infectious Diseases workshop on Atopic dermatitis and the atopic march: Mechanisms and interventions''

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:143

Article

Davidson, Wendy F.¹  Leung, Donald Y. M.^2,3  Beck, Lisa A.⁴  Berin, Cecilia M.⁵  Boguniewicz, Mark^2,6  Busse, William W.⁷  Chatila, Talal A.⁸  Geha, Raif S.^9,10  Gern, James E.⁷  Guttman-Yassky, Emma^11,12,13  Irvine, Alan D.^14,15,16  Kim, Brian S.^17,18,19  Kong, Heidi H.^20,32  Lack, Gideon²¹  Nadeau, Kari C.^22,23  Schwaninger, Julie¹  Simpson, Angela²⁴  Simpson, Eric L.²⁵  Spergel, Jonathan M.^26,27  Togias, Alkis¹  Wahn, Ulrich²⁸  Wood, Robert A.²⁹  Woodfolk, Judith A.³⁰  Ziegler, Steven F.³¹  Plaut, Marshall¹ 

[1] NIAID, NIH, Rockville, MD USA

[2] Natl Jewish Hlth, Dept Pediat, 1400 Jackson St,Room K926i, Denver, CO 80206 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Aurora, CO USA

[4] Univ Rochester, Med Ctr, Rochester, NY 14627 USA

[5] Icahn Sch Med Mt Sinai, Dept Pediat, Mindich Child Hlth & Dev Inst, Inst Immunol, New York, NY 10029 USA

[6] Univ Colorado, Sch Med, Aurora, CO USA

[7] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53706 USA

[8] Harvard Med Sch, Div Immunol, Dept Pediat, Boston Childrens Hosp, Boston, MA 02115 USA

[9] Harvard Med Sch, Div Immunol, Childrens Hosp, Boston, MA 02115 USA

[10] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[11] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA

[12] Icahn Sch Med Mt Sinai, Lab Inflammatory Skin Dis, New York, NY 10029 USA

[13] Rockefeller Univ, Invest Dermatol Lab, 1230 York Ave, New York, NY 10021 USA

[14] Our Ladys Childrens Hosp, Paediat Dermatol, Crumlin, Ireland

[15] Natl Childrens Res Ctr, Dublin, Ireland

[16] Trinity Coll Dublin, Dublin, Ireland

[17] Washington Univ, Sch Med, Ctr Study Itch, Div Dermatol,Dept Med, St Louis, MO 63130 USA

[18] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63130 USA

[19] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA

[20] NCI, Dermatol Branch, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA

[21] Guys & St Thomas NHS Fdn Trust, Kings Coll London,Dept Women & Childrens Hlth, Peter Gorer Dept Immunobiol,Fac Life Sci & Med, Sch Life Course Sci,Paediat Allergy, London, England

[22] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA

[23] Stanford Univ, Dept Med, Dept Pediat, Stanford, CA 94305 USA

[24] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Infect Immun & Resp Med, Sch Biol Sci, Manchester, Lancs, England

[25] Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97201 USA

[26] Childrens Hosp Philadelphia, Dept Pediat, Div Allergy & Immunol, Philadelphia, PA 19104 USA

[27] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[28] Charite, Dept Pediat Pneumol & Immunol, Berlin, Germany

[29] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[30] Univ Virginia, Sch Med, Dept Med, Charlottesville, VA 22908 USA

[31] Benaroya Res Inst, Program Immunol, Seattle, WA USA

[32] NIAMSD, Dermatol Branch, NIH, Bethesda, MD 20892 USA

关键词: Atopic march;    atopic dermatitis;    food allergy;    asthma;    skin barrier;    skin microbiome;    biomarkers;    interventions;   

DOI  :  10.1016/j.jaci.2019.01.003

来源: Elsevier

【 摘 要 】

Atopic dermatitis (AD) affects up to 20% of children worldwide and is an increasing public health problem, particularly in developed countries. Although AD in infants and young children can resolve, there is a well-recognized increased risk of sequential progression from AD to other atopic diseases, including food allergy (FA), allergic rhinitis, allergic asthma, and allergic rhinoconjunctivitis, a process referred to as the atopic march. The mechanisms underlying the development of AD and subsequent progression to other atopic comorbidities, particularly FA, are incompletely understood and the subject of intense investigation. Other major research objectives are the development of effective strategies to prevent AD and FA, as well as therapeutic interventions to inhibit the atopic march. In 2017, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop to discuss current understanding and important advances in these research areas and to identify gaps in knowledge and future research directions. International and national experts in the field were joined by representatives from several National Institutes of Health institutes. Summaries of workshop presentations, key conclusions, and recommendations are presented herein.

【 授权许可】

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