Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:138

Article

Gupta, Jayanta¹  Johansson, Elisabet¹  Bernstein, Jonathan A.³  Chakraborty, Ranajit⁴  Hershey, Gurjit K. Khurana¹  Rothenberg, Marc E.²  Mersha, Tesfaye B.¹ 

[1] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Asthma Res, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Allergy & Immunol, Cincinnati, OH 45229 USA

[3] Univ Cincinnati, Dept Internal Med, Div Immunol, Allergy Sect, Cincinnati, OH 45267 USA

[4] Univ North Texas Hlth Sci Ctr, Ctr Computat Genom, Inst Appl Genet, Dept Mol & Med Genet, Ft Worth, TX USA

关键词: Atopic march;    food allergy;    atopic dermatitis;    allergic rhinitis;    asthma;    racial ancestry;    admixture mapping;    phenotyping;    gene-environment interaction;    -omics;   

DOI  :  10.1016/j.jaci.2016.02.045

来源: Elsevier

【 摘 要 】

Atopic dermatitis (AD), food allergy, allergic rhinitis, and asthma are common atopic disorders of complex etiology. The frequently observed atopic march from early AD to asthma, allergic rhinitis, or both later in life and the extensive comorbidity of atopic disorders suggest common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African Americans when compared with European Americans. Whether this disparity stems from true genetic or race-specific environmental risk factors or both is unknown. Thus far, the majority of the genetic studies on atopic diseases have used populations of European ancestry, limiting their generalizability. Large-cohort initiatives and new analytic methods, such as admixture mapping, are currently being used to address this knowledge gap. Here we discuss the unique and shared genetic risk factors for atopic disorders in the context of ancestry variations and the promise of high-throughput -omics''-based systems biology approach in providing greater insight to deconstruct their genetic and nongenetic etiologies. Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, gene-environment, and gene-gene interactions.

【 授权许可】

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