International consensus on allergy immunotherapy

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:136

Article

Jutel, Marek^1,2  Agache, Ioana³  Bonini, Sergio^4,5,6  Burks, A. Wesley⁷  Calderon, Moises⁸  Canonica, Walter⁹  Cox, Linda¹⁰  Demoly, Pascal¹¹  Frew, Antony J.¹²  O'Hehir, Robin¹³  Kleine-Tebbe, Joerg¹⁴  Muraro, Antonella¹⁵  Lack, Gideon^16,17  Larenas, Desiree¹⁸  Levin, Michael¹⁹  Nelson, Harald²⁰  Pawankar, Ruby²¹  Pfaar, Oliver²²  van Ree, Ronald^23,24  Sampson, Hugh^25,26  Santos, Alexandra F.^27,28  Du Toit, George^27,28  Werfel, Thomas²⁹  van Wijk, Roy Gerth³⁰  Zhang, Luo³¹  Akdis, Cezmi A.³² 

[1] Wroc1aw Med Univ, Dept Clin Immunol, PL-50368 Wroclaw, Poland

[2] ALL MED Med Res Inst, Wroclaw, Poland

[3] Transylvania Univ, Fac Med, Brasov, Romania

[4] Univ Naples 2, Rome, Italy

[5] IFT CNR, Rome, Italy

[6] Expert On Secondment European Med Agcy, London, England

[7] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA

[8] Royal Brompton Hosp, Sect Allergy & Clin Immunol, Imperial Coll London, Natl Heart & Lung Inst, London SW3 6LY, England

[9] Univ Genoa, DIMI, Allergy & Resp Dis Clin, IRCCS AOU S Martino, Genoa, Italy

[10] Ctr Asthma & Allergy, Ft Lauderdale, FL USA

[11] Univ Hosp Montpellier, INSERM U657, Montpellier, France

[12] Royal Sussex Cty Hosp, Dept Resp Med, Brighton BN2 5BE, E Sussex, England

[13] Monash Univ, AMREP, Dept Immunol, Melbourne, Vic 3004, Australia

[14] Allergy & Asthma Ctr Westend, Berlin, Germany

[15] Padua Gen Univ Hosp, Dept Mother & Child Hlth, Padua, Italy

[16] Kings Coll London, MRC & Asthma UK Ctr Allerg Mech Asthma, Div Asthma Allergy & Lung Biol, London WC2R 2LS, England

[17] Guys & St Thomas NHS Fdn Trust, Childrens Allergy Unit, London, England

[18] Hosp Med Sur, Mexico City, DF, Mexico

[19] Red Cross War Mem Childrens Hosp, Div Allergy, Sch Child & Adolescent Hlth, Cape Town, South Africa

[20] Natl Jewish Hlth, Denver, CO USA

[21] Nippon Med Sch, Dept Pediat, Tokyo 113, Japan

[22] Univ Hosp Mannheim, Ctr Rhinol & Allergol, Dept Otorhinolaryngol Head & Neck Surg, Mannheim, Germany

[23] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1012 WX Amsterdam, Netherlands

[24] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands

[25] Icahn Sch Med Mt Sinai, Dept Pediat, Div Allergy Immunol, New York, NY 10029 USA

[26] Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, New York, NY 10029 USA

[27] Kings Coll London, Div Asthma Allergy & Lung Biol, Dept Pediat Allergy, London WC2R 2LS, England

[28] MRC & Asthma UK Ctr Allerg Mech Asthma, London, England

[29] Hannover Med Sch, Dept Dermatol & Allergy, Div Immunodermatol & Allergy Res, Hannover, Germany

[30] Erasmus MC, Rotterdam, Netherlands

[31] Beijing Inst Otolaryngol, Beijing, Peoples R China

[32] Univ Zurich, Swiss Inst Allergy & Asthma Res, Christine Kuhne Ctr Allergy Res & Educ, Davos, Switzerland

关键词: International consensus;    allergy;    immunotherapy;    allergen vaccine;    allergic rhinitis;    asthma;    food allergy;    atopic dermatitis;   

DOI  :  10.1016/j.jaci.2015.04.047

来源: Elsevier

【 摘 要 】

Allergen immunotherapy (AIT) has been used to treat allergic disease since the early 1900s. Despite numerous clinical trials and meta-analyses proving AIT efficacious, it remains underused and is estimated to be used in less than 10% of patients with allergic rhinitis or asthma worldwide. In addition, there are large differences between regions, which are not only due to socioeconomic status. There is practically no controversy about the use of AIT in the treatment of allergic rhinitis and allergic asthma, but for atopic dermatitis or food allergy, the indications for AIT are not well defined. The elaboration of a wider consensus is of utmost importance because AIT is the only treatment that can change the course of allergic disease by preventing the development of asthma and new allergen sensitizations and by inducing allergen-specific immune tolerance. Safer and more effective AIT strategies are being continuously developed both through elaboration of new allergen preparations and adjuvants and alternate routes of administration. A number of guidelines, consensus documents, or both are available on both the international and national levels. The international community of allergy specialists recognizes the need to develop a comprehensive consensus report to harmonize, disseminate, and implement the best AIT practice. Consequently, the International Collaboration in Asthma, Allergy and Immunology, formed by the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma & Immunology; and the World Allergy Organization, has decided to issue an international consensus on AIT.

【 授权许可】

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