JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 卷:137 |
International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics | |
Article | |
Jutel, Marek1,2  Agache, Ioana3  Bonini, Sergio4,5,6  Burks, Wesley7  Calderon, Moises8  Canonica, Walter9  Cox, Linda10  Demoly, Pascal11  Frew, Antony J.12  O'Hehir, Robyn13,14  Kleine-Tebbe, Joerg15  Muraro, Antonella16  Lack, Gideon17,18,19  Larenas, Desiree20  Levin, Michael21  Martin, Bryan L.22  Nelson, Harald23  Pawankar, Ruby24  Pfaar, Oliver25  van Ree, Ronald26,27  Sampson, Hugh28,29  Sublett, James L.30  Sugita, Kazunari31,32  Du Toit, George33,34,35  Werfel, Thomas36  van Wijk, Roy Gerth37  Zhang, Luo38  Akdis, Muebeccel31,32  Akdis, Cezmi A.31,32  | |
[1] Wroclaw Med Univ, Dept Clin Immunol, Chalubinskiego 5, PL-50368 Wroclaw, Poland | |
[2] ALL MED Med Res Inst, Wroclaw, Poland | |
[3] Transylvania Univ, Fac Med, Brasov, Romania | |
[4] Univ Naples 2, Rome, Italy | |
[5] IFT CNR, Rome, Italy | |
[6] Expert On Secondment European Med Agcy, London, England | |
[7] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA | |
[8] Univ London Imperial Coll Sci Technol & Med, Sect Allergy & Clin Immunol, Natl Heart & Lung Inst, Royal Brompton Hosp, London SW7 2AZ, England | |
[9] DIMI Univ Genoa, Allergy & Resp Dis Clin, IRCCS AOU San Martino, Genoa, Italy | |
[10] Ctr Asthma & Allergy, Ft Lauderdale, FL USA | |
[11] Univ Hosp Montpellier, INSERM, U657, Montpellier, France | |
[12] Royal Sussex Cty Hosp, Dept Resp Med, Brighton, E Sussex, England | |
[13] Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia | |
[14] Monash Univ, Melbourne, Vic, Australia | |
[15] Allergy & Asthma Ctr Westend, Berlin, Germany | |
[16] Padua Gen Univ Hosp, Dept Mother & Child Hlth, Padua, Italy | |
[17] MRC, Div Asthma Allergy & Lung Biol, London W1N 4AL, England | |
[18] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London WC2R 2LS, England | |
[19] Guys & St Thomas NHS Fdn Trust, Childrens Allergy Unit, London, England | |
[20] Hosp Med Sur, Mexico City, DF, Mexico | |
[21] Red Cross War Mem Childrens Hosp, Sch Child & Adolescent Hlth, Div Allergy, Cape Town, South Africa | |
[22] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Silver Spring, MD USA | |
[23] Natl Jewish Hlth, Denver, CO USA | |
[24] Nippon Med Sch, Dept Pediat, 1-1-5 Sendagi, Tokyo 113, Japan | |
[25] Univ Hosp Mannheim, Ctr Rhinol & Allergol, Dept Otorhinolaryngol Head & Neck Surg, Mannheim, Germany | |
[26] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1012 WX Amsterdam, Netherlands | |
[27] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands | |
[28] Icahn Sch Med Mt Sinai, Dept Pediat, Div Allergy Immunol, New York, NY 10029 USA | |
[29] Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, New York, NY 10029 USA | |
[30] Univ Louisville, Sch Med, Sect Allergy & Immunol, Dept Pediat, Louisville, KY 40292 USA | |
[31] Univ Zurich, Swiss Inst Allergy & Asthma Res, CH-8006 Zurich, Switzerland | |
[32] Christine Kuhne Ctr Allergy Res & Educ, Davos, Switzerland | |
[33] Kings Coll London, Div Asthma Allergy & Lung Biol, Dept Pediat Allergy, London WC2R 2LS, England | |
[34] MRC, London W1N 4AL, England | |
[35] Asthma UK Ctr Allerg Mech Asthma, London, England | |
[36] Hannover Med Sch, Div Immunodermatol & Allergy Res, Dept Dermatol & Allergy, Hannover, Germany | |
[37] Erasmus MC, Rotterdam, Netherlands | |
[38] Beijing Inst Otolaryngol, Beijing, Peoples R China | |
关键词: International consensus; allergy; immunotherapy; allergen vaccine; allergen standardization; pharmacoeconomics; cost-effectiveness; mechanisms; tolerance; marketing authorization; regulatory authorities; unmet needs; | |
DOI : 10.1016/j.jaci.2015.12.1300 | |
来源: Elsevier | |
【 摘 要 】
This article continues the comprehensive international consensus (ICON) statement on allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers to and facilitators of the use of AIT are described in addition to future directions. International allergy specialists representing the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma and Immunology; and the World Allergy Organization critically reviewed the existing literature and prepared this summary of recommendations for best AIT practice. The authors contributed equally and reached consensus on the statements presented herein.
【 授权许可】
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