The Consortium for Food Allergy Research (CoFAR): The first generation

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:143

Review

Sampson, Hugh A.¹  Berin, M. Cecilia¹  Plaut, Marshall²  Sicherer, Scott H.¹  Jones, Stacie^3,4  Burks, A. Wesley⁵  Lindblad, Robert⁶  Leung, Donald Y. M.⁷  Wood, Robert A.⁸ 

[1] Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, New York, NY 10029 USA

[2] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA

[4] Arkansas Childrens Hosp, 800 Marshall St, Little Rock, AR 72202 USA

[5] Univ N Carolina, Dept Pediat, Chapel Hill, NC 27515 USA

[6] Emmes Corp, Rockville, MD USA

[7] Natl Jewish Hlth, Dept Pediat, Denver, CO USA

[8] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

关键词: Food allergy;    peanut allergy;    egg allergy;    immunotherapy;    oral immunotherapy;    sublingual immunotherapy;    epicutaneous immunotherapy;   

DOI  :  10.1016/j.jaci.2018.12.989

来源: Elsevier

【 摘 要 】

The Consortium for Food Allergy Research (CoFAR) was established by the National Institute of Allergy and Infectious Diseases in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. CoFAR was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration an observational study of infants with milk and egg allergy was established, and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut allergy were initiated, as was a phase 1 study of a recombinant peanut protein vaccine. CoFAR was renewed in 2010 for an additional 5-year period during which the initial observational study was continued, a study of eosinophilic esophagitis was initiated, and new therapeutic trials were established to study epicutaneous immunotherapy for peanut allergy and to compare the safety and efficacy of egg oral immunotherapy to the ingestion of baked egg for the treatment of egg allergy. The results of these efforts will be reviewed in this rostrum, with a brief look to the future of CoFAR.

【 授权许可】

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