Prevention of food allergy

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:137

Article

du Toit, George^1,2,3  Tsakok, Teresa^4,5  Lack, Simon⁶  Lack, Gideon^1,2,3 

[1] Guys & St Thomas NHS Fdn Trust, MRC, Kings Hlth Partners, Kings Coll London, Westminster Bridge Rd, London SE1 7EH, England

[2] Guys & St Thomas NHS Fdn Trust, Asthma UK Ctr Allerg Mech Asthma, Westminster Bridge Rd, London SE1 7EH, England

[3] Guys & St Thomas NHS Fdn Trust, Dept Paediat Allergy, Westminster Bridge Rd, London SE1 7EH, England

[4] Guys & St Thomas NHS Fdn Trust, Kings Coll London, Westminster Bridge Rd, London SE1 7EH, England

[5] Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, Westminster Bridge Rd, London SE1 7EH, England

[6] Univ London Imperial Coll Sci Technol & Med, London, England

关键词: Food allergy;    atopic dermatitis;    peanut allergy;    cow's milk allergy;    egg allergy;    oral food challenge;    specific IgE;   

DOI  :  10.1016/j.jaci.2016.02.005

来源: Elsevier

【 摘 要 】

The past few decades have witnessed an increase in the prevalence of IgE-mediated food allergy (FA). For prevention strategies to be effective, we need to understand the causative factors underpinning this rise. Genetic factors are clearly important in the development of FA, but given the dramatic increase in prevalence over a short period of human evolution, it is unlikely that FA arises through germline genetic changes alone. Aplausible hypothesis is that 1 or more environmental exposures, or lack thereof, induce epigenetic changes that result in interruption of the default immunologic state of tolerance. Strategies for the prevention of FA might include primary prevention, which seeks to prevent the onset of IgE sensitization; secondary prevention, which seeks to interrupt the development of FA in IgE-sensitized children; and tertiary prevention, which seeks to reduce the expression of end-organ allergic disease in children with established FA. This review emphasizes the prevention of IgE-mediated FA through dietary manipulation, among other strategies; in particular, we focus on recent interventional studies in this field.

【 授权许可】

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