Effect of acellular pertussis vaccine on the development of allergic sensitization to environmental allergens in adults

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:105

Article

Assa'ad, A ; Lierl, M

关键词: adult;    allergens;    Bordetella pertussis;    hypersensitivity;    IgE;    hospital personnel;    pertussis toxin;    pertussis vaccine;    RAST;    vaccines;   

DOI  :  10.1016/S0091-6749(00)90193-3

来源: Elsevier

【 摘 要 】

Background: Exposure of children to pertussis antigens caused by infection or vaccination with whole-cell pertussis vaccine may increase the serum IgE level and predispose to sensitization to the prevalent environmental allergens. Acellular pertussis vaccine (APV) that may be given to adults may have a similar effect. Objective: The purpose of this study was to determine whether APV will cause an increase in environmental sensitization measured by an increase of serum-specific IgE to the allergens to which adults are exposed during the vaccination period. Methods: One hundred adult hospital employees were randomized to receive either a a component APV composed of pertussis toxin and filamentous hemagglutinin or a meningococcal vaccine as a control, Serum-specific IgE level to 2 indoor allergens, cat and dust mite, and 2 outdoor allergens prevalent during the immunization season, Alternaria species and ragweed, was measured by an RIA on sera collected before and 1 month after vaccination. Results: The group that received the APV had no significant change in their serum-specific IgE levels to cat, dust Alternaria species, or ragweed 1 month after vaccination. Conclusion: A 2-component APV did not predispose to an increase of allergen-specific IgE in an adult population.

【 授权许可】

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