Systemic responses after bronchial aspirin challenge in sensitive patients with asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:121

Article

Makowska, Joanna S.¹  Grzegorczyk, Janina²  Bienkiewicz, Barbara¹  Wozniak, Maria³  Kowalski, Marek L.¹ 

[1] Med Univ Lodz, Chair Immunol, Dept Rheumatol Immunol & Allergy, Fac Med, PL-92215 Lodz, Poland

[2] Med Univ Lodz, Fac Pharm, Dept Immunol Diagnost, PL-92215 Lodz, Poland

[3] Allergy Clin, Plock, Poland

关键词: aspirin hypersensitivity;    bronchial asthma;    AERD;    progenitor cells;    CD34;    aspirin bronchial challenge;   

DOI  :  10.1016/j.jaci.2007.09.039

来源: Elsevier

【 摘 要 】

Background: In aspirin-sensitive patients with asthma, bronchial obstruction induced by oral aspirin may be associated with extrabronchial symptoms, suggesting the systemic character of the response. Objective: Go assess potential systemic effects of local aspirin challenge, hemopoietic progenitors were measured in the peripheral blood of challenged patients. Methods: In 19 patients with a history of aspirin-induced asthma, placebo-controlled bronchial challenges with lysineaspirin were performed. Peripheral blood was collected before and then 1 hour and 20 hours after challenge (placebo or aspirin). Using the flow-cytometric method, the numbers of leukocyte (CD34(+) cells) and eosinophil (CD34(+)CD125(+) cells) progenitors were determined. Results: The challenge was positive in 13 patients; 6 patients had isolated local bronchial reaction, and 7 patients developed systemic symptoms (bronchial and extrabronchial). In patients with positive challenge (n = 13), leukocyte progenitors increased significantly at 1 hour and 20 hours after challenge (mean, 0.04% at baseline, 0.066% at 1 hour after challenge, and 0.073% at 20 hours; P < .05). Eosinophil progenitors raised significantly from mean 0.017% before challenge to 0.04% (P < .05) at 20 hours after the challenge. At 20 hours after the challenge, the increase in leukocyte and eosinophil progenitors was observed only in patients with systemic reactions. Positive aspirin challenge was associated with a significant increase in eotaxin 2 serum concentration. Conclusion: This study demonstrated that bronchial challenge with aspirin may involve systemic reactions and is associated with mobilization of leukocyte and eosinophil progenitor cells from the bone marrow.

【 授权许可】

Free